About

Meijo Univeristy

Kageyama Lab

Professor

Hakuto Kageyama, Ph.D.

Meijo University
1-501 Shiogamaguchi, Tempaku-ku, Nagoya 468-8502 Japan

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Research

01

Mycosporine-like amino acids（MAAs）

Cyanobacteria produce various secondary metabolites in response to environmental stresses. One of these is the ultraviolet absorbing substance "mycosporine-like amino acid (MAA)" that accumulates in the cells of cyanobacteria to protect themselves from ultraviolet (UV) irradiation stress. MAAs have the property of efficiently absorbing and neutralizing wavelengths in the UV-A and UV-B ranges. Because UV-A and UV-B cause sunburn and inflammation due to sunburn, MAAs are functional compounds that have attracted attention, such as being commercialized as a natural sunscreen ingredient.

We discovered that the salt-tolerant cyanobacterium Halothece sp. PCC7418 strain synthesizes mycosporine-2-glycine (M2G), a type of MAA, in response to salt (NaCl) stress. Furthermore, we have revealed that M2G has excellent skin quality improving effects, such as antioxidant effects, anti-glycation effects, and collagenase inhibition effects. Currently, we are conducting research with the aim of creating microorganisms capable of mass-producing M2G by utilizing the M2G biosynthesis genes of Halothece sp. PCC7418.

Since MAA is induced by environmental factors such as salt stress as well as ultraviolet radiation stress and temperature stress, we are continually attempting to isolate cyanobacteria strains that live in special environments such as high salt concentrations, high light intensity and high temperatures in the hopes of discovering new MAAs. We are also developing a process for extracting MAAs from seaweed.

02

Saclipin

Recently, we discovered that Aphanothece sacrum, a cyanobacterium endemic to Japan that has long been sold as a luxury food in parts of Kyushu, produces a new UV absorbing substance. This substance has a structure completely different from known UV-absorbing substances such as MAAs that have been found in cyanobacteria. We named this substance 'saclipin', and are currently studying its properties and biosynthetic pathway.

We found that saclipin has two structures, saclipin A and saclipin B, which are cis-trans isomers. Saclipin A and saclipin B absorb UV-A and UV-B wavelengths well, and also exhibit antioxidant and anti-glycation activities that contribute to anti-aging. We also found that they inhibit elastase activity, inhibit tyrosinase activity, suppress melanin production, and promote the production of collagen and hyaluronic acid, all of which improve skin quality. Saclipins have been demonstrated to be a chemically stable compound against light and heat, and no cytotoxicity was observed, making them promising natural compounds for use in skin care cosmetics. Part of the synthesis process of saclipins was also clarified, including the fact that saclipins are produced during the drying process of Aphanothece sacrum, and that saclipin A can be converted to saclipin B by an isomerization reaction caused by light irradiation treatment.

03

Environmental adaptation mechanisms of cyanobacteria

Cyanobacteria are distributed all over the world, and some species can grow in extreme environments, such as deserts and salt lakes. For example, Halothece sp. PCC7418 strain, isolated from the Dead Sea, is a cyanobacterium that can grow in extremely high salt environments. In order to adjust the osmotic pressure inside the cell with that of the extracellular environment, such salt-tolerant cyanobacteria synthesize an osmotically compatible solute called glycine betaine (GB) and accumulate it in high concentrations intracellularly. In addition, transporters have a mechanism for actively excreting harmful sodium ions outside the cell.

We have been conducting research focusing on the regulatory mechanisms of the biosynthetic pathway of compatible solutes in salt-tolerant cyanobacteria and the properties of transporters. So far, the mechanism for supplying glycine, which is necessary for large production of GB, and the mechanism for producing the energy required for biosynthesis were unknown, but comprehensive gene expression analyses have revealed that many of the genes involved in the amino acid metabolic pathway leading to glycine biosynthesis and energy production are upregulated in response to salt stress. It was also revealed that the genes that make up the system that maintains protein homeostasis were also strongly induced. These findings suggest that salt-tolerant cyanobacteria activate key metabolic pathways when they sense salt stress, thereby adapting to high salt concentration.

In addition to salt-tolerant cyanobacteria, we have been researching unique cyanobacterial strains that have stress tolerance, such as desiccation tolerance and high temperature tolerance.

Publications

Original
Review
Book
Book chapter
Commentary
Media

Original articles

2025

  1. Uchida Y, Honda M, Waditee-Sirisattha R, Kageyama H. 2025. Functional evaluation of saclipins A and B derived from the edible cyanobacterium Aphanothece sacrum: New bioactivities for anti-wrinkle and anti-hypertension. AIMS Molecular Science 12:113-121.
  2. Ito M, Honda M, Kageyama H. 2025. Extraction and isomerization of ultraviolet-absorbing substances, saclipins, from an edible cyanobacterium Aphanothece sacrum using subcritical water. The Journal of Supercritical Fluids 217:106459.

2024

  1. Aono T, Samsri S, Waditee-Sirisattha R, Kageyama H. 2024. Draft genome sequence of a cyanobacterium Gloeocapsa sp. BRSZ, isolated from Bo Khlueng hot spring in Ratchaburi, Thailand. Microbiology Resource Announcements 13:e00681-24.
  2. Waditee-Sirisattha R, Kageyama H. 2024. Novel NhaC N+/H+ antiporter in cyanobacteria contributes to key molecular processes for salt tolerance. Plant Molecular Biology 114:111.
  3. Uchida Y, Honda M, Waditee-Sirisattha R, Kageyama H. 2024. Photo- and thermo-chemical properties and biological activities of saclipins, UV-absorbing compounds derived from the cyanobacterium Aphanothece sacrum. ACS Agricultural Science & Technology 4:1260-1270.
  4. Samsri S, Kortheerakul C, Kageyama H, Waditee-Sirisattha R. 2024. Molecular and biochemical characterization of a plant-like iota-class glutathione S-transferase from the halotolerant cyanobacterium Halothece sp. PCC7418. Journal of Applied Microbiology 135.
  5. Phuphanitcharoenkun S, Louis F, Sowa Y, Uchida K, Katsuyama M, Waditee-Sirisattha R, Kageyama H, Matsusaki M, Palaga T. 2024. Characterization of macrophages associated with human skin models exposed to UV radiation. Communications Biology 7:1284.
  6. Kageyama H, Honda M, Nakamura R, Waditee-Sirisattha R, Kamohara S. 2024. Processing-induced changes in components that affect the radical scavenging activity of ethanolic extracts from Neopyropia yezoensis. AIMS Molecular Science 11:251-261.
  7. Honda M, Zhang Y, Kageyama H, Hibino T, Goto M, Nishida Y. 2024. Formation and characterization of Z-isomer-enriched carotenoid-loaded microparticles with poly(vinylpyrrolidone) using a spray drying technique. Industrial & Engineering Chemistry Research 63:383-393.
  8. Honda M, Zhang Y, Kageyama H, Hibino T, Goto M, Nishida Y. 2024. Development of a continuous production system for Z-isomer-rich carotenoid/2-hydroxypropyl-β-cyclodextrin inclusion complexes using a flow reactor and a spray dryer. Food and Bioproducts Processing 143:221-231.

2023

  1. Uchida Y, Maoka T, Palaga T, Honda M, Tode C, Shimizu M, Waditee-Sirisattha R, Kageyama H. 2023. Identification of desiccation stress-inducible antioxidative and antiglycative ultraviolet-absorbing oxylipins, saclipin A and saclipin B, in an edible cyanobacterium Aphanothece sacrum. Journal of Agricultural and Food Chemistry 71:16137-16147.
  2. Ngoennet S, Sirisattha S, Kusolkumbot P, Hibino T, Kageyama H, Waditee-Sirisattha R. 2023. Active role of the protein translation machinery in protecting against stress tolerance in Synechococcus elongatus PCC7942. Archives of Biochemistry and Biophysics 746:109734.

2022

  1. Waditee-Sirisattha R, Kageyama H. 2022. Global transcriptome analyses and regulatory mechanisms in Halothece sp. PCC 7418 exposed to abiotic stresses. Applied Microbiology and Biotechnology 106:6641-6655.
  2. Waditee-Sirisattha R, Ito H, Kageyama H. 2022. Global transcriptional and circadian regulation in a halotolerant cyanobacterium Halothece sp. PCC7418. Scientific Reports 12:13190.
  3. Murakami K, Kageyama H, Hibino T, Zhang Y, Goto M, Honda M. 2022. Preparation of highly stable Z-isomer-rich lycopene nanodispersions via a continuous-flow system with selected emulsifiers. European Journal of Lipid Science and Technology 124:2200034.
  4. Honda M, Kageyama H, Zhang Y, Hibino T, Goto M. 2022. Oral supplementation with Z-isomer-rich astaxanthin inhibits ultraviolet light-induced skin damage in guinea pigs. Marine Drugs 20:414.

2021

  1. Waditee-Sirisattha R, Kageyama H. 2021. Protective effects of mycosporine-like amino acid-containing emulsions on UV-treated mouse ear tissue from the viewpoints of antioxidation and antiglycation. Journal of Photochemistry and Photobiology B: Biology 223:112296.
  2. Patipong T, Kageyama H, Waditee-Sirisattha R. 2021. Insights into the phylogeny and transcriptional response of serine proteases in a halotolerant cyanobacterium Halothece sp. PCC7418. Plant Signaling & Behavior 16:1913556.
  3. Kortheerakul C, Kageyama H, Waditee-Sirisattha R. 2021. Molecular and functional insights into glutathione S-transferase genes associated with salt stress in Halothece sp. PCC7418. Plant, Cell and Environment 44:3583-3596.
  4. Honda M, Kageyama H, Murakami K, Hibino T, Osawa Y, Kawashima Y, Wasai M, Hirasawa K, Kuroda I. 2021. Isomerization of Paracoccus carotinifaciens-derived carotenoids (astaxanthin, adonirubin, and adonixanthin) under subcritical water conditions. ACS Food Science & Technology 1:1861-1868.
  5. Honda M, Kageyama H, Hibino T, Osawa Y, Kawashima Y, Hirasawa K, Kuroda I. 2021. Evaluation and improvement of storage stability of astaxanthin isomers in oils and fats. Food Chemistry 352:129371.

2020

  1. Patipong T, Hibino T, Kageyama H, Waditee-Sirisattha R. 2020. The evolutionarily conserved HtrA is associated with stress tolerance and protein homeostasis in the halotolerant cyanobacterium Halothece sp. PCC7418. Extremophiles 24:377-389.
  2. Ngoennet S, Sirisattha S, Honda M, Hibino T, Kageyama H, Waditee-Sirisattha R. 2020. Morphological plasticity of hyperelongated cells caused by overexpression of translation elongation factor P in Synechococcus elongatus PCC7942. Applied Microbiology and Biotechnology 104:8801-8812.
  3. Ngoennet S, Honda M, Patipong T, Hibino T, Waditee-Sirisattha R, Kageyama H. 2020. The effects of salts and osmoprotectants on enzyme activities of fructose-1,6-biphosphate aldolases in a halotolerant cyanobacterium, Halothece sp. PCC 7418. Life (Basel) 10:23.
  4. Korteerakul C, Honda M, Ngoennet S, Hibino T, Waditee-Sirisattha R, Kageyama H. 2020. Antioxidative and antiglycative properties of mycosporine-like amino acids-containing aqueous extracts derived from edible terrestrial cyanobacteria. Journal of Nutritional Science and Vitaminology 66:339-346.
  5. Honda M, Kageyama H, Hibino T, Sowa T, Kawashima Y. 2020. Efficient and environmentally friendly method for carotenoid extraction from Paracoccus carotinifaciens utilizing naturally occurring Z-isomerization-accelerating catalysts. Process Biochemistry 89:146-154.
  6. Honda M, Kageyama H, Hibino T, Ichihashi K, Takada W, Goto M. 2020. Isomerization of commercially important carotenoids (lycopene, beta-carotene, and astaxanthin) by natural catalysts: Isothiocyanates and polysulfides. Journal of Agricultural and Food Chemistry 68:3228-3237.
  7. Honda M, Kageyama H, Hibino T, Ichihashi K, Takada W, Goto M. 2020. Synergistic effects of food ingredients and vegetable oils on thermal isomerization of lycopene. Journal of Oleo Science 69:1529-1540.

2019

  1. Tarasuntisuk S, Palaga T, Kageyama H, Waditee-Sirisattha R. 2019. Mycosporine-2-glycine exerts anti-inflammatory and antioxidant effects in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Archives of Biochemistry and Biophysics 662:33-39.
  2. Pingkhanont P, Tarasuntisuk S, Hibino T, Kageyama H, Waditee-Sirisattha R. 2019. Expression of a stress-responsive gene cluster for mycosporine-2-glycine confers oxidative stress tolerance in Synechococcus elongatus PCC7942. FEMS Microbiology Letters 366:fnz115.
  3. Patipong T, Ngoennet S, Honda M, Hibino T, Waditee-Sirisattha R, Kageyama H. 2019. A class I fructose-1,6-bisphosphate aldolase is associated with salt stress tolerance in a halotolerant cyanobacterium Halothece sp. PCC 7418. Archives of Biochemistry and Biophysics 672:108059.
  4. Patipong T, Hibino T, Waditee-Sirisattha R, Kageyama H. 2019. Induction of antioxidative activity and antioxidant molecules in the halotolerant cyanobacterium Halothece sp. PCC7418 by temperature shift. Natural Product Communications 14:1-6.
  5. Janchot K, Rauytanapanit M, Honda M, Hibino T, Sirisattha S, Praneenararat T, Kageyama H, Waditee-Sirisattha R. 2019. Effects of potassium chloride-induced stress on the carotenoids canthaxanthin, astaxanthin, and lipid accumulations in the green Chlorococcal microalga strain TISTR 9500. Journal of Eukaryotic Microbiology 66:778-787.
  6. Honda M, Kageyama H, Hibino T, Zhang Y, Ichihashi K, Fukaya T, Goto M. 2019. Impact of global traditional seasonings on thermal Z-isomerization of (all-E)-lycopene in tomato puree. Lwt 116:108565.
  7. Honda M, Kageyama H, Hibino T, Zhang Y, Diono W, Kanda H, Yamaguchi R, Takemura R, Fukaya T, Goto M. 2019. Improved carotenoid processing with sustainable solvents utilizing Z-isomerization-induced alteration in physicochemical properties: A review and future directions. Molecules 24:2149.
  8. Honda M, Kageyama H, Hibino T, Waditee‐Sirisattha R, Fukaya T, Hayashi Y, Goto M. 2019. Chemical‐free approach for Z‐Isomerization of lycopene in tomato powder: Hot air and superheated steam heating above the melting point of lycopene. European Journal of Lipid Science and Technology 122:1900327.
  9. Honda M, Kageyama H, Hibino T, Takemura R, Goto M, Fukaya T. 2019. Enhanced Z-isomerization of tomato lycopene through the optimal combination of food ingredients. Scientific Reports 9:7979.
  10. Atikij T, Syaputri Y, Iwahashi H, Praneenararat T, Sirisattha S, Kageyama H, Waditee-Sirisattha R. 2019. Enhanced lipid production and molecular dynamics under salinity stress in green microalga Chlamydomonas reinhardtii (137C). Marine Drugs 17:484.

2018

  1. Yamamori T, Kageyama H, Tanaka Y, Takabe T. 2018. Requirement of alkanes for salt tolerance of cyanobacteria: characterization of alkane synthesis genes from salt-sensitive Synechococcus elongatus PCC7942 and salt-tolerant Aphanothece halophytica. Letters in Applied Microbiology 67:299-305.
  2. Tarasuntisuk S, Patipong T, Hibino T, Waditee-Sirisattha R, Kageyama H. 2018. Inhibitory effects of mycosporine-2-glycine isolated from a halotolerant cyanobacterium on protein glycation and collagenase activity. Letters in Applied Microbiology 67:314-320.
  3. Phogosee S, Hibino T, Kageyama H, Waditee-Sirisattha R. 2018. Bifunctional alanine dehydrogenase from the halotolerant cyanobacterium Aphanothece halophytica: characterization and molecular properties. Archives of Microbiology 200:719-727.
  4. Ngoennet S, Nishikawa Y, Hibino T, Waditee-Sirisattha R, Kageyama H. 2018. A method for the isolation and characterization of mycosporine-like amino acids from cyanobacteria. Methods and Protocols 1:46.
  5. Kageyama H, Tanaka Y, Takabe T. 2018. Biosynthetic pathways of glycinebetaine in Thalassiosira pseudonana; functional characterization of enzyme catalyzing three-step methylation of glycine. Plant Physiology and Biochemistry 127:248-255.
  6. Kageyama H, Tanaka Y, Shibata A, Waditee-Sirisattha R, Takabe T. 2018. Dimethylsulfoniopropionate biosynthesis in a diatom Thalassiosira pseudonana: Identification of a gene encoding MTHB-methyltransferase. Archives of Biochemistry and Biophysics 645:100-106.
  7. Honda M, Kodama T, Kageyama H, Hibino T, diono W, Kanda H, Goto M. 2018. Enhanced solubility and reduced crystallinity of carotenoids, β-carotene and astaxanthin, by Z-isomerization. European Journal of Lipid Science and Technology 120:1800191
  8. Dawut K, Sirisattha S, Hibino T, Kageyama H, Waditee-Sirisattha R. 2018. Functional characterization of the NhaA Na+/H+ antiporter from the green picoalga Ostreococcus tauri. Archives of Biochemistry and Biophysics 649:37-46.

2017

  1. Waditee-Sirisattha R, Kageyama H, Tanaka Y, Fukaya M, Takabe T. 2017. Overexpression of halophilic serine hydroxymethyltransferase in fresh water cyanobacterium Synechococcus elongatus PCC7942 results in increased enzyme activities of serine biosynthetic pathways and enhanced salinity tolerance. Archives of Microbiology 199:29-35.
  2. Patipong T, Hibino T, Waditee-Sirisattha R, Kageyama H. 2017. Efficient bioproduction of mycosporine-2-glycine, which functions as potential osmoprotectant, using Escherichia coli cells. Natural Product Communications 12:1593-1594.

2016

  1. Cheewinthamrongrod V, Kageyama H, Palaga T, Takabe T, Waditee-Sirisattha R. 2016. DNA damage protecting and free radical scavenging properties of mycosporine-2-glycine from the Dead Sea cyanobacterium in A375 human melanoma cell lines. Journal of Photochemistry and Photobiology B: Biology 164:289-295.

Pre-2015

  1. Yamada N, Theerawitaya C, Kageyama H, Cha-Um S, Takabe T. 2015. Expression of developmentally regulated plasma membrane polypeptide (DREPP2) in rice root tip and interaction with Ca2+/CaM complex and microtubule. Protoplasma 252:1519-27.
  2. Waditee-Sirisattha R, Kageyama H, Fukaya M, Rai V, Takabe T. 2015. Nitrate and amino acid availability affects glycine betaine and mycosporine-2-glycine in response to changes of salinity in a halotolerant cyanobacterium Aphanothece halophytica. FEMS Microbiology Letters 362:fnv198.
  3. Kageyama H, Waditee-Sirisattha R, Sirisattha S, Tanaka Y, Mahakhant A, Takabe T. 2015. Improved alkane production in nitrogen-fixing and halotolerant cyanobacteria via abiotic stresses and genetic manipulation of alkane synthetic genes. Current Microbiology 71:115-120.
  4. Kageyama H, Waditee-Sirisattha R, Sirisattha S, Tanaka Y, Mahakhant A, Takabe T. 2015. Extraction and quantification of alkanes in cyanobacteria. Bio-protocol 5:e1684.
  5. Charuchinda P, Waditee-Sirisattha R, Kageyama H, Yamada D, Sirisattha S, Tanaka Y, Mahakhant A, Takabe T. 2015. Caleosin from Chlorella vulgaris TISTR 8580 is salt-induced and heme-containing protein. Biosci Bioscience, Biotechnology, and Biochemistry 79:1119-24.
  6. Bualuang A, Kageyama H, Tanaka Y, Incharoensakdi A, Takabe T. 2015. Functional characterization of a member of alanine or glycine: cation symporter family in halotolerant cyanobacterium Aphanothece halophytica. Bioscience, Biotechnology, and Biochemistry 79:230-5.
  7. Waditee-Sirisattha R, Kageyama H, Sopun W, Tanaka Y, Takabe T. 2014. Identification and upregulation of biosynthetic genes required for accumulation of mycosporine-2-glycine under salt stress conditions in the halotolerant cyanobacterium Aphanothece halophytica. Applied and Environmental Microbiology 80:1763-1769.
  8. Tripathi K, Sharma NK, Kageyama H, Takabe T, Rai AK. 2013. Physiological, biochemical and molecular responses of the halophilic cyanobacterium Aphanothece halophytica to Pi-deficiency. European Journal of Phycology 48:461-473.
  9. Waditee-Sirisattha R, Singh M, Kageyama H, Sittipol D, Rai AK, Takabe T. 2012. Anabaena sp. PCC7120 transformed with glycine methylation genes from Aphanothece halophytica synthesized glycine betaine showing increased tolerance to salt. Archives of Microbiology 194:909-14.
  10. Yamada N, Cha-Um S, Kageyama H, Promden W, Tanaka Y, Kirdmanee C, Takabe T. 2011. Isolation and characterization of proline/betaine transporter gene from oil palm. Tree Physiology 31:462-8.
  11. Soontharapirakkul K, Promden W, Yamada N, Kageyama H, Incharoensakdi A, Iwamoto-Kihara A, Takabe T. 2011. Halotolerant cyanobacterium Aphanothece halophytica contains an Na+-dependent F1F0-ATP synthase with a potential role in salt-stress tolerance. Journal of Biological Chemistry 286:10169-10176.
  12. Kageyama H, Tripathi K, Rai AK, Cha-Um S, Waditee-Sirisattha R, Takabe T. 2011. An alkaline phosphatase/phosphodiesterase, PhoD, induced by salt stress and secreted out of the cells of Aphanothece halophytica, a halotolerant cyanobacterium. Applied and Environmental Microbiology 77:5178-5183.
  13. Kageyama H, Ueda H, Tezuka T, Ogasawara A, Narita Y, Kageyama T, Ichinose M. 2010. Differences in the P1' substrate specificities of pepsin A and chymosin. The Journal of Biochemistry 147:167-74.
  14. Yoshida T, Murayama Y, Ito H, Kageyama H, Kondo T. 2009. Nonparametric entrainment of the in vitro circadian phosphorylation rhythm of cyanobacterial KaiC by temperature cycle. Proceedings of the National Academy of Sciences USA 106:1648-1653.
  15. Ito H, Kageyama H, Mutsuda M, Nakajima M, Oyama T, Kondo T. 2007. Autonomous synchronization of the circadian KaiC phosphorylation rhythm. Nature Structural & Molecular Biology 14:1084-8.
  16. Kageyama H, Nishiwaki T, Nakajima M, Iwasaki H, Oyama T, Kondo T. 2006. Cyanobacterial circadian pacemaker: Kai protein complex dynamics in the KaiC phosphorylation cycle in vitro. Molecular Cell 23:161-171.
  17. Nishiwaki T, Satomi Y, Nakajima M, Lee C, Kiyohara R, Kageyama H, Kitayama Y, Temamoto M, Yamaguchi A, Hijikata A, Go M, Iwasaki H, Takao T, Kondo T. 2004. Role of KaiC phosphorylation in the circadian clock system of Synechococcus elongatus PCC 7942. Proceedings of the National Academy of Sciences USA 101:13927-13932.
  18. Kageyama H, Kondo T, Iwasaki H. 2003. Circadian formation of clock protein complexes by KaiA, KaiB, KaiC, and SasA in cyanobacteria. Journal of Biological Chemistry 278:2388-95.

Review articles

  1. Kageyama H, Waditee-Sirisattha R. 2023. Distribution, biosynthetic regulation, and bioactivities of mycosporine-2-glycine, a rare UV-protective mycosporine-like amino acid. AIMS Molecular Science 10:295-310.
  2. Waditee-Sirisattha R, Kageyama H. 2023. Halotolerance, stress mechanisms, and circadian clock of salt-tolerant cyanobacteria. Applied Microbiology and Biotechnology 107:1129-1141.
  3. Kageyama H, Waditee-Sirisattha R. 2019. Antioxidative, anti-inflammatory, and anti-aging properties of mycosporine-like amino acids: molecular and cellular mechanisms in the protection of skin-aging. Marine Drugs 17:222.
  4. Honda M, Kageyama H, Hibino T, Zhang Y, Diono W, Kanda H, Yamaguchi R, Takemura R, Fukaya T, Goto M. 2019. Improved carotenoid processing with sustainable solvents utilizing Z-isomerization-induced alteration in physicochemical properties: A review and future directions. Molecules 24:2149.
  5. Waditee-Sirisattha R, Kageyama H, Takabe T. 2016. Halophilic microorganism resources and their applications in industrial and environmental biotechnology. AIMS Microbiology 2:42-54.

Books

  1. 景山伯春. 2024. マイコスポリン様アミノ酸入門 増訂第2版. 三恵社.
  2. Kageyama H. 2023. An Introduction to Mycosporine-Like Amino Acids. Bentham Science Publishers.
  3. Kageyama H, Waditee-Sirisattha R (ed). 2022. Cyanobacterial Physiology: From Fundamentals to Biotechnology. Elsevier.
  4. 景山伯春. 2021. マイコスポリン様アミノ酸入門. 三恵社.

Book chapters

  1. Kageyama H, Waditee-Sirisattha R. 2023. Engineering Cyanobacteria for the Synthesis of Novel Products, p 161-169. In Singh SP, Sinha, RP, Häder DP (eds), Methods in Cyanobacterial Research. CRC press.
  2. Kageyama H, Waditee-Sirisattha R. 2023. Halotolerance mechanisms in salt‑tolerant cyanobacteria, p 55-117. In Gadd GM (eds), Advances in Applied Microbiology, vol 124. Elsevier.
  3. Kageyama H, Hibino T, Waditee-Sirisattha R. 2023. A transcriptome analysis of the model cyanobacterium Synechococcus elongatus PCC7942 under severe salinity and antibiotic atress conditons, p 43-63. In Grant CD (ed), Advences in Biology, vol 4. Nova Science Publishers.
  4. Waditee-Sirisattha R, Kageyama H. 2022. Extremophilic cyanobacteria, p 85-99. In Kageyama H, Waditee-Sirisattha R (ed), Cyanobacterial Physiology: From Fundamentals to Biotechnology. Elsevier.
  5. Waditee-Sirisattha R, Kageyama H. 2022. Cyanobacterial cells, p 3-16. In Kageyama H, Waditee-Sirisattha R (ed), Cyanobacterial Physiology: From Fundamentals to Biotechnology. Elsevier.
  6. Kageyama H, Waditee-Sirisattha R. 2022. Mycosporine-like amino acids and scytonemin: Regulations, roles for adaptation of cyanobacteria to the environment, and potential applications, p 101-111. In Kageyama H, Waditee-Sirisattha R (ed), Cyanobacterial Physiology: From Fundamentals to Biotechnology. Elsevier.
  7. Kageyama H, Waditee-Sirisattha R. 2022. Osmoprotectant molecules in cyanobacteria: Their basic features, biosynthetic regulations, and potential applications, p 113-123. In Kageyama H, Waditee-Sirisattha R (ed), Cyanobacterial Physiology: From Fundamentals to Biotechnology. Elsevier.
  8. Kageyama H, Honda M, Hibino T, Waditee-Sirisattha R. 2022. Natural compounds derived from cyanobacteria: potential benefits and applicability to skin-care, p 189-212. In Sinha RP (ed), Cyanobacteria: Life History, Ecology and Impact on Humans. Nova Science Publishers.
  9. Waditee-Sirisattha R, Honda M, Hibino T, Kageyama H. 2021. Potential inhibitory effects of plant and cyanobacteria-derived natural products on advanced glycation end-product formation, p 201-224. In Ansari NA (ed), A Closer Look at Glycation: A Potential Hotspot for Age-Related Complications and Diseases. Nova Science Publishers.
  10. Waditee-Sirisattha R, Kageyama H. 2020. Sensing and molecular mechanisms of salt-stress tolerance in cyanobacteria, p 213-232. In Berhardt LV (ed), Advances in Medicine and Biology, vol 171. NOVA Science Publishers.
  11. Kageyama H, Waditee-Sirisattha R. 2018. Cyanobacterial UV sunscreen: Biosynthesis, regulation, and application, p 1-28. In Rastogi RP (ed), Sunscreens: Source, Formulations, Efficacy and Recommendations. NOVA Science Publishers.
  12. Kageyama H, Waditee-Sirisattha R. 2018. Mycosporine-like amino acids as multifunctional secondary metabolites in cyanobacteria: From biochemical to application aspects, p 153-194. In Atta-ur-Rahman (ed), Studies in Natural Products Chemistry, vol 59. Elsevier.
  13. Kageyama H, Waditee-Sirisattha R, Tanaka Y, Takabe T. 2017. Osmoprotectant and sunscreen molecules from halophilic algae and cyanobacteria, p 1-16, Algal Green Chemistry. Elsevier.

Commentary

  1. Kageyama H, Waditee-Sirisattha R. 2025. Bioactive ultraviolet-absorbing compounds derived from cyanobacteria and microalgae. AIMS Molecular Science 12:26-31.
  2. 景山 伯春. 2022. 天然のスキンケア原料：マイコスポリン様アミノ酸. 生物工学会誌 100:674-674.

Media

  1. 2024年11月29日 HAPPI 「Saclipins in A. sacrum Show Potential in Skincare: Study」
    https://www.happi.com/breaking-news/saclipins-in-a-sacrum-show-potential-in-skincare-study/
  2. 2024年11月21日 EurekAlert!「Natural saclipins offer hope of combating skin aging: A new frontier in skin health」
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